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Poly(lactic acid) based hydrogels.

Arijit Basu1, Konda Reddy Kunduru1, Sindhu Doppalapudi2

  • 1School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, and Jerusalem College of Engineering (JCE), Jerusalem 91120, Israel.

Advanced Drug Delivery Reviews
|July 20, 2016
PubMed
Summary
This summary is machine-generated.

This review explores polylactide (PLA) hydrogels for biomedical uses. PLA hydrogels are synthesized and characterized for drug delivery and tissue engineering applications.

Keywords:
HydrogelIn situ hydrogelPLAPLA–PEGResponsive polymerThermo-responsive

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Chemical Engineering

Background:

  • Hydrogels are crucial for biomedical applications like drug delivery and tissue engineering.
  • Polylactide (PLA) and its copolymers are hydrophobic polyesters, necessitating modification for hydrogel formation.
  • Copolymerization with hydrophilic monomers or conjugation creates functional PLA-based hydrogels.

Purpose of the Study:

  • To review the synthesis and characterization of polylactide (PLA)-containing hydrogels.
  • To highlight the diverse applications of these advanced hydrogel materials.
  • To discuss the tailored properties, including stimulus responsiveness and shape memory.

Main Methods:

  • Copolymerization of lactides with hydrophilic monomers (e.g., polyethylene glycol).
  • Utilizing various crosslinking mechanisms: physical (hydrophobic interactions, stereocomplexation, ionic) and chemical (radical, photo).
  • Incorporation of urethane bonds for shape memory properties.

Main Results:

  • PLA-based hydrogels exhibit tunable properties, including thermo-responsiveness.
  • Multiple crosslinking strategies enable tailored hydrogel architectures and functionalities.
  • PLA hydrogels can be designed for specific stimuli-responsive behaviors (pH, photo, redox) and shape memory effects.

Conclusions:

  • Polylactide-containing hydrogels offer versatile platforms for advanced biomedical applications.
  • The synthesis and characterization methods discussed provide a foundation for developing novel drug delivery systems and tissue scaffolds.
  • Future research can further exploit the unique properties of PLA hydrogels for regenerative medicine and targeted therapies.