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Acitretin.

Marcus G Tan1, Neil H Shear1,2, Scott Walsh1,2

  • 11 Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Journal of Cutaneous Medicine and Surgery
|July 20, 2016
PubMed
Summary
This summary is machine-generated.

Acitretin monotherapy did not improve intractable hidradenitis suppurativa (HS). However, when used with other systemic medications, acitretin showed significant improvement in HS patients.

Keywords:
acitretinadjuvant therapycombined therapyhidradenitis suppurativamonotherapy

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Hidradenitis suppurativa (HS) is a chronic inflammatory disease impacting quality of life.
  • Managing intractable HS presents clinical challenges.
  • Acitretin's efficacy in HS has been explored in limited case series.

Purpose of the Study:

  • To evaluate the effectiveness of acitretin in treating severe, treatment-resistant hidradenitis suppurativa.
  • To compare acitretin monotherapy versus its use as an adjuvant treatment for HS.

Main Methods:

  • Retrospective review of HS patients treated with acitretin from 2011-2015.
  • Inclusion of patients receiving acitretin as monotherapy or with other systemic agents.
  • Assessment of clinical response using the physician global scale.

Main Results:

  • Fourteen patients with advanced HS (Hurley stage II/III) were analyzed.
  • No improvement was observed in patients receiving acitretin monotherapy (n=6).
  • Significant clinical improvement occurred in 87.5% of patients using acitretin adjunctively (n=8).

Conclusions:

  • Acitretin monotherapy is not effective for intractable hidradenitis suppurativa.
  • Acitretin demonstrates potential efficacy as an adjuvant therapy for HS when combined with other systemic medications.