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CD30+ lymphoproliferative disorder with spindle-cell morphology.

Kathryn J Martires1, Brandon E Cohen2, David S Cassarino3

  • 1The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA.

Journal of Cutaneous Pathology
|July 20, 2016
PubMed
Summary

Lymphomatoid papulosis (LyP), a CD30+ skin disease, can present with varied histology. This case reveals a unique LyP subtype with atypical CD30+ spindle-shaped cells, potentially a new variant.

Keywords:
CD30 positive lymphoproliferative disorderlymphomatoid papulosisprimary cutaneous anaplastic large cell lymphomaprimary cutaneous lymphoproliferative diseasespindle cells

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Area of Science:

  • Dermatopathology
  • Oncology
  • Immunohistochemistry

Background:

  • Lymphomatoid papulosis (LyP) is a CD30+ primary cutaneous lymphoproliferative disorder.
  • LyP exhibits diverse histologic subtypes (Types A-F), reflecting phenotypic variability.
  • CD30+ lymphoproliferative diseases require precise classification for accurate diagnosis and management.

Observation:

  • A case of LyP in an elderly woman presented with unusual histopathologic findings.
  • The atypical CD30+ infiltrate demonstrated a distinct spindle-cell morphology.
  • This morphology was not previously described in established LyP subtypes.

Findings:

  • The study reports the first case of LyP characterized by CD30+ spindle-shaped cells.
  • This unique presentation suggests a potential novel histologic variant of LyP.
  • Immunohistochemical analysis confirmed the CD30 positivity and spindle-cell nature of the infiltrate.

Implications:

  • Recognition of this spindle-cell variant is crucial for accurate diagnosis of LyP.
  • This finding expands the known spectrum of CD30+ cutaneous lymphoproliferative diseases.
  • Further research may elucidate the specific characteristics and clinical behavior of this potential new LyP variant.