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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
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Skin aging: are adipocytes the next target?
Ilja L Kruglikov1, Philipp E Scherer2
1Scientific Department, Wellcomet GmbH, Karlsruhe, Germany.
Aging
|July 20, 2016
Summary
Dermal white adipose tissue (dWAT) volume decreases with skin aging, particularly photo-aging. This reduction is linked to adipocyte-myofibroblast transition, suggesting dWAT is a key target for anti-aging strategies.
Area of Science:
- Dermatology
- Adipose Tissue Biology
- Skin Aging Research
Background:
- Dermal white adipose tissue (dWAT) plays unique roles in skin homeostasis.
- dWAT volume is significantly altered during intrinsic and extrinsic skin aging.
- Photo-damaged skin shows reduced dWAT volume due to adipocyte loss.
Purpose of the Study:
- To investigate the role of dWAT in skin aging.
- To explore the mechanisms behind dWAT reduction in aged skin.
- To identify dWAT as a potential target for anti-aging interventions.
Main Methods:
- Review of existing literature on dWAT and skin aging.
- Analysis of cellular processes involved in dWAT modulation.
- Correlation studies between dWAT, scarring, and skin aging signs.
Main Results:
- Chronic photo-damage leads to dWAT reduction, with adipocytes replaced by fibrotic tissue.
- Adipocyte-myofibroblast transition (AMT) is a likely mechanism for dWAT loss.
- dWAT adipocyte changes correlate with skin aging signs and hypertrophic scarring.
Conclusions:
- Dermal adipocytes are significantly impacted by skin aging processes.
- AMT is a key factor in dWAT reduction observed in aged skin.
- Targeting dWAT may offer novel strategies for combating skin aging.
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