[EARLY COMPLICATIONS IN PATIENTS, OPERATED FOR NEUROENDOCRINE TUMORS OF PANCREATIC GLAND]

Area of Science:

• Gastroenterology and Hepatology
• Surgical Oncology
• Endocrinology

Context:

• Neuroendocrine pancreatic tumors (NET) are rare neoplasms requiring specialized surgical management.
• Postoperative complications following pancreatic surgery for NET can be significant, impacting patient outcomes.
• Understanding prognostic factors is crucial for optimizing surgical strategies and reducing morbidity.

Purpose:

• To analyze early postoperative complications in patients treated surgically for neuroendocrine pancreatic tumors (NET).
• To identify significant prognostic factors influencing complication rates in both resectional and organ-preserving pancreatic NET surgeries.
• To evaluate the efficacy of an elaborated diagnostic-treatment algorithm in reducing surgical complications.

Summary:

• A total of 154 patients with NET underwent analysis for early complications. Operative interventions included 82 resectional and 56 organ-preserving procedures.
• External pancreatic fistula was the most frequent complication. Tumor proximity to the pancreatic duct (organ-preserving) and low pancreatic tissue density (resectional) were key prognostic factors.
• The implemented diagnostic-treatment algorithm reduced overall complication rates from 36.8% to 15%, with specific reductions in resectional (30% to 11.3%) and organ-preserving (44.4% to 21%) surgeries.

Impact:

• The study highlights critical prognostic factors influencing surgical complications in pancreatic NET.
• The developed algorithm demonstrates a significant reduction in postoperative morbidity associated with pancreatic NET surgery.
• Findings provide a basis for refining surgical approaches and improving patient outcomes in the management of pancreatic NET.