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Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
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Radiosurgery for infundibulum adenoma: stalk dose implications.
Jennifer D Sokolowski1, Or Cohen-Inbar2,3, Jason P Sheehan2
1Department of Neurological Surgery, University of Virginia, PO Box 800212, Charlottesville, VA, 22908, USA. soko@virginia.edu.
Acta Neurochirurgica
|July 21, 2016
Summary
Stereotactic radiosurgery (SRS) offers a viable treatment for infundibular pituitary adenomas, preserving function. Gamma Knife surgery (GKS) demonstrated sustained tumor control and maintained endocrine and visual function in a recurrent case.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Endocrinology
Background:
- Treating infundibular pituitary adenomas with stereotactic radiosurgery (SRS) is challenging due to the need to preserve pituitary endocrine and visual functions.
- Recurrent lesions pose a particular management difficulty, often requiring multimodal treatment approaches.
Observation:
- A case of a recurrent infundibular lesion, previously treated with two microsurgical resections, was managed with Gamma Knife surgery (GKS).
- The lesion was treated with a single SRS session, delivering a margin dose of 15 Gy to the infundibulum.
Findings:
- Five years post-GKS, the patient exhibited persistent tumor regression.
- Crucially, no visual dysfunction or hypopituitarism was observed, indicating preserved pituitary endocrine function.
- The study suggests that radiosurgical doses up to 30 Gy to the pituitary stalk may be safely tolerated.
Implications:
- SRS, specifically GKS, can be an effective treatment option for residual or recurrent infundibular pituitary adenomas.
- This approach offers a potential strategy for tumor control while safeguarding vital pituitary and visual functions.
- The findings support the tolerability of specific SRS doses for the pituitary stalk, informing future treatment planning.
