[Effect of vephylline on hexobarbital metabolism after single and multiple administrations]

The purpose of the present study is to evaluate the influence of a new Bulgarian original preparation Verphyline on hexobarbital metabolism. The studies were carried out on white male rats of Wistar strain after single and multiple administrations. After single administration Verphyline prolongs the duration of hexobarbital sleep (HBS), which accompanies elevated serum concentrations of hexobarbital (S-HB) and inhibits the activity of hexobarbital oxidase (HBO). After a 4-day period of treatment with Verphyline shortening of HBS is observed, reduction of sera levels of hexobarbital and activation of HBO. Biotransformation of the examined preparation is most probably connected with liver microsomal enzymic systems and changes of their activity after multiple applications.