Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

6.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
6.0K
Bone Remodeling01:40

Bone Remodeling

40.9K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.9K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

4.6K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.6K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

4.2K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
4.2K
What is the Skeletal System?01:02

What is the Skeletal System?

58.6K
Overview
58.6K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

5.9K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Commissioning of the novel Continuous Angle Multi-energy Analysis spectrometer at the Paul Scherrer Institut.

The Review of scientific instruments·2023
Same author

[Endocrinology and pregnancy].

Deutsche medizinische Wochenschrift (1946)·2023
Same author

[Adrenal gland diseases].

Deutsche medizinische Wochenschrift (1946)·2022
Same author

[Autoimmune diseases of the thyroid gland].

Deutsche medizinische Wochenschrift (1946)·2021
Same author

[Diabetes complications].

Deutsche medizinische Wochenschrift (1946)·2020
Same author

[Thyroid Nodules].

Deutsche medizinische Wochenschrift (1946)·2020
Same journal

[In process].

Medizinische Monatsschrift fur Pharmazeuten·2018
Same journal

[In process].

Medizinische Monatsschrift fur Pharmazeuten·2018
Same journal

[In process].

Medizinische Monatsschrift fur Pharmazeuten·2018
Same journal

[In process].

Medizinische Monatsschrift fur Pharmazeuten·2018
Same journal

[In process].

Medizinische Monatsschrift fur Pharmazeuten·2018
Same journal

[In process].

Medizinische Monatsschrift fur Pharmazeuten·2018
See all related articles

Related Experiment Video

Updated: Mar 17, 2026

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
07:20

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

1.1K

[Osteoporosis].

Gerhard Hintze, Dieter Graf

    Medizinische Monatsschrift Fur Pharmazeuten
    |July 22, 2016
    PubMed
    Summary
    This summary is machine-generated.

    Osteoporosis, a leading cause of bone fractures, affects older adults, particularly women. Diagnosis uses dual X-ray absorptiometry, with bisphosphonates as a key treatment.

    Related Experiment Videos

    Last Updated: Mar 17, 2026

    Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
    07:20

    Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

    Published on: August 23, 2024

    1.1K

    Area of Science:

    • Gerontology
    • Orthopedics
    • Endocrinology

    Context:

    • Osteoporosis is a significant global health concern, primarily leading to bone fractures.
    • Age and sex are critical factors influencing osteoporosis prevalence, with higher incidence in older women.

    Purpose:

    • To provide a comprehensive overview of osteoporosis, including its prevalence, diagnostic methods, and treatment strategies.
    • To summarize current understanding and management approaches for osteoporosis.

    Summary:

    • The prevalence of osteoporosis escalates with age, disproportionately affecting women.
    • Dual X-ray absorptiometry is the standard diagnostic tool.
    • Pharmacological treatment often involves bisphosphonates, alongside adequate calcium and vitamin D intake for prophylaxis.

    Impact:

    • This overview aids healthcare professionals in understanding and managing osteoporosis effectively.
    • Highlights the importance of early diagnosis and appropriate therapeutic interventions to reduce fracture risk.