Related Experiment Video
Updated: Jul 21, 2026

Detection of Ligand-activated G Protein-coupled Receptor Internalization by Confocal Microscopy
Published on: April 9, 2017
[Electron microscopic study of internalization stages of cellular receptors for insulin and alpha-1-thymosin]
Abstract:
Initial stages of insulin-receptor interaction in two types of blood cells (erythrocytes and monocytes) as well as of thymosin-receptor interaction in thymic lymphocytes of rat were studied by electron microscope. Hormone-receptor complexes were marked by colloidal gold. There was general similarity at the initial stages of interaction of both peptide hormones and cellular, membrane receptors for them. Some characteristic and regular ultrastructural peculiarities were described in distribution, aggregation and early links of internalization of insulin-binding and thymosin-binding receptor sites, which could be taken into consideration analysing hormone-receptor interaction and of its defects at receptor and postreceptor level.
More Related Videos
09:41Confocal Imaging of Neuropeptide Y-pHluorin: A Technique to Visualize Insulin Granule Exocytosis in Intact Murine and Human Islets
Published on: September 13, 2017
08:34Precise Visualization of Insulin Receptors A and B in Murine Brain with an RNA In Situ Hybridization Assay
Published on: July 15, 2025
Related Concept Videos
Receptor-mediated Endocytosis
Intracellular Hormone Receptors
Receptor-mediated Endocytosis
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
The Early Endosome: Endocytosis of Transferrin
Insulin Secretory Vesicles
Insulin: The Receptor and Signaling Pathways