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Updated: Mar 17, 2026

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation
Published on: July 23, 2012
MicroRNAs differentially expressed in Behçet disease are involved in interleukin-6 production
Min-Yeong Woo1,2, Su Jin Yun1,2, Okki Cho1,2
1Department of Microbiology, Ajou University School of Medicine, Youngtongku Wonchondong San 5, Suwon, 442-749 Korea.
Background:
Behcet's disease (BD) is characterized by systemic recurrent inflammation with increased production of tumor necrosis factor (TNF)-α and interleukin (IL)-6 by peripheral blood mononuclear cells (PBMCs). To gain insight into the underlying mechanisms of this disease, the expression levels of distinct microRNAs in PBMCs of BD patients were determined and their association with TNF-α and IL-6 production was evaluated.
Findings:
The expression levels of microRNAs, miR-638 and miR-4488, were reduced in patients with stable BD in comparison with healthy controls. In addition, the expression of miR-3591-3p was increased in patients with active BD when compared to patients with stable BD. Transfection of miR-638 and miR-4488 inhibitors, together with miR-3591-3p mimics, increased IL-6 mRNA levels in THP-1 cells in response to LPS stimulation.
Conclusions:
We observed differential expression of microRNAs associated with increased production of IL-6 in BD patients.
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