Related Experiment Video

Updated: Mar 17, 2026

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
04:25

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

11.9K

Emerging concepts for PI3K/mTOR inhibition as a potential treatment for osteosarcoma

Michael W Bishop1, Katherine A Janeway2

  • 1Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA; Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA.

F1000Research
|July 22, 2016
PubMed

Insights

New therapeutic strategies targeting the phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway show promise for osteosarcoma patients. Preclinical studies indicate PI3K/mTOR inhibition can reduce tumor cell growth and induce apoptosis, warranting clinical investigation.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Metastatic and recurrent osteosarcoma have poor prognoses, necessitating novel therapeutic approaches.
  • Genomic and pathway analyses reveal frequent aberrations in the phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway in osteosarcoma.
  • Current therapeutic options for advanced osteosarcoma are limited.

Purpose of the Study:

  • To investigate the therapeutic potential of targeting the PI3K/mTOR pathway in osteosarcoma.
  • To evaluate the efficacy of PI3K/mTOR inhibition as a strategy for osteosarcoma treatment.

Main Methods:

  • Analysis of genomic and pathway data in murine and human osteosarcoma models.
  • Preclinical evaluation of PI3K and mTOR inhibition using single agents and dual inhibitors.
  • Assessment of effects on cell proliferation, cell cycle arrest, and apoptosis.

Main Results:

  • Common aberrations in the PI3K/mTOR pathway were identified in osteosarcoma.
  • Inhibition of PI3K/mTOR decreased osteosarcoma cell proliferation.
  • PI3K/mTOR inhibition induced cell cycle arrest and apoptosis in preclinical models.

Conclusions:

  • The PI3K/mTOR pathway represents a potential therapeutic vulnerability in osteosarcoma.
  • Targeting PI3K/mTOR warrants further clinical investigation for osteosarcoma treatment.
  • Developing novel therapeutic strategies for osteosarcoma is crucial for improving patient survival.
Keywords:
PI3Kinhibition treatmentmTORosteosarcoma

More Related Videos

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

2.4K
Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

13.4K

Related Concept Videos

PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
6.2K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.0K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

1.6K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.9K