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Early, late, and sequential embryo transfer in in vitro fertilization program: a preliminary report
1Department of Obstetrics and Gynecology, Assaf Harofe Medical Centre, Zerifin, Israel.
Fertility and Sterility
|July 1, 1989
Summary
Embryo transfer (ET) timing and sequential transfers showed no significant impact on pregnancy rates. Delaying embryo transfer or using sequential transfers did not offer advantages over standard protocols.
Area of Science:
- Reproductive Medicine
- Embryology
- In Vitro Fertilization
Background:
- Optimizing embryo transfer (ET) timing is crucial for successful in vitro fertilization (IVF) outcomes.
- Previous research suggests developmental stage at ET influences pregnancy rates.
- The potential benefits of sequential embryo transfers remain under investigation.
Purpose of the Study:
- To evaluate the impact of different embryo transfer timings on pregnancy rates.
- To compare single versus sequential embryo transfers.
- To determine if delaying ET or performing sequential transfers improves IVF success.
Main Methods:
- Fifty-one patients undergoing IVF were randomized into three groups.
- Embryos were transferred at 44-48 hours post-insemination, 68-72 hours post-insemination, or sequentially at both time points.
- Embryo morphology and blastomere count were assessed.
Main Results:
- Embryos transferred at 68-72 hours had significantly more blastomeres (P < 0.0001).
- Embryo morphology was comparable across all groups.
- Pregnancy rates were similar: 53% (44-48h), 59% (68-72h), and 47% (sequential).
Conclusions:
- There is likely no advantage to delaying embryo transfer or performing sequential transfers.
- Sequential embryo transfer does not appear to be associated with adverse effects on pregnancy rates.
- Current evidence suggests single embryo transfers at either early or later developmental stages yield comparable outcomes.