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Functional Connectivity with the Default Mode Network Is Altered in Fibromyalgia Patients
Nicholas Fallon1, Yee Chiu2, Turo Nurmikko3,4
1Department of Psychological Sciences, Institute of Psychology, Health, and Society, University of Liverpool, Liverpool, United Kingdom.
Plos One
|July 22, 2016
Summary
Fibromyalgia patients exhibit altered brain connectivity within the default mode network (DMN). These DMN connectivity changes are linked to symptom duration, pain, and depression in fibromyalgia syndrome (FMS).
Area of Science:
- Neuroscience
- Medical Imaging
- Psychiatry
Background:
- Fibromyalgia syndrome (FMS) is characterized by widespread pain and cognitive difficulties.
- Altered brain activity and connectivity are implicated in FMS pathophysiology.
- The default mode network (DMN) plays a crucial role in maintaining resting-state brain activity.
Purpose of the Study:
- To investigate resting-state functional connectivity patterns of the DMN in FMS patients.
- To explore the relationship between DMN connectivity alterations and clinical symptoms in FMS.
Main Methods:
- Seed-based functional connectivity analysis using resting-state MRI.
- Comparison of DMN connectivity between 16 female FMS patients and 15 healthy controls.
- Correlation analysis between DMN connectivity and symptom duration, tenderness, and depression scores.
Main Results:
- FMS patients showed altered connectivity between DMN structures and the anterior midcingulate cortex, right parahippocampal gyrus, left superior parietal lobule, and left inferior temporal gyrus.
- Reduced DMN connectivity with the right parahippocampal gyrus correlated with longer symptom duration.
- Increased connectivity between anterior and posterior cingulate cortices correlated with tenderness and depression scores.
Conclusions:
- Fibromyalgia syndrome is associated with significant alterations in DMN functional connectivity.
- These connectivity changes involve brain regions critical for pain, cognitive, and emotional processing.
- DMN alterations may contribute to the chronic symptoms experienced by FMS patients.
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