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Amino Acid Sensing in Skeletal Muscle

Tatiana Moro1, Scott M Ebert2, Christopher M Adams2

  • 1Department of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, TX, USA; Sealy Center on Aging, University of Texas Medical Branch, Galveston, TX, USA.

Trends in Endocrinology and Metabolism: TEM
|July 23, 2016
PubMed
Summary

Aging impairs muscle protein synthesis, leading to weakness. Amino acid sensing pathways involving mTORC1 and ATF4 are key to muscle aging and may offer strategies to combat sarcopenia.

Keywords:
activating transcription factor 4general control nonderepressible 2leucinemammalian/mechanistic target of rapamycin complex 1tomatidineursolic acid

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