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Further Simplification of the Simple Erosion Narrowing Score With Item Response Theory Methodology
Martijn A H Oude Voshaar1, Olga Schenk1, Peter M Ten Klooster1
1University of Twente, Enschede, The Netherlands.
Arthritis Care & Research
|July 23, 2016
Summary
Simplifying the Simple Erosion Narrowing Score (SENS) by removing carpal joints maintains measurement performance. This optimized SENS offers a more precise tool for assessing rheumatoid arthritis progression.
Area of Science:
- Rheumatology
- Medical Imaging
- Biostatistics
Background:
- The Simple Erosion Narrowing Score (SENS) is a tool used to assess joint damage in rheumatoid arthritis.
- Item Response Theory (IRT) analysis can identify areas contributing least to measurement precision.
Purpose of the Study:
- To simplify the SENS by removing less informative scored areas.
- To compare the measurement performance of a simplified SENS with the original version.
Main Methods:
- Longitudinal IRT methodology was applied to data from the COBRA trial.
- Measurement precision, discriminant validity, and responsiveness were evaluated for SENS and its simplified version.
Main Results:
- Carpal and feet joints contributed the least statistical information to SENS.
- Omitting carpal joints minimally affected measurement precision (77-88% relative efficiency).
- A simplified SENS without carpal joints demonstrated similar responsiveness and discriminant validity to the original SENS.
Conclusions:
- The carpal joints can be omitted from the SENS without significantly impacting its measurement performance.
- A simplified SENS offers a potentially more efficient tool for assessing joint damage in rheumatoid arthritis.
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