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Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for
Irwin K Cheah1, Lei Feng2, Richard M Y Tang1
1Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore.
Ergothioneine (ET) levels in blood significantly decrease after age 60. Lower ET plasma levels were observed in individuals with mild cognitive impairment, suggesting a potential link to neurodegenerative diseases.
Area of Science:
- Biochemistry
- Gerontology
- Neuroscience
Background:
- Ergothioneine (ET) is a naturally occurring thione found in diet and accumulates in the human body.
- ET is absorbed via the OCTN1 transporter and may concentrate in tissues with high oxidative stress and inflammation.
- ET possesses potential cytoprotective effects.
Purpose of the Study:
- To investigate the age-related changes in ergothioneine (ET) levels within the human body.
- To explore the relationship between ET levels and cognitive status in elderly individuals.
Main Methods:
- Analysis of whole blood and plasma ergothioneine (ET) levels in elderly individuals.
- Comparison of ET levels between age-matched subjects and those with mild cognitive impairment.
Main Results:
- Whole blood ET levels showed a significant decline in individuals over 60 years of age.
- Plasma ET levels were significantly lower in elderly subjects with mild cognitive impairment compared to controls.
Conclusions:
- Age-related decline in ergothioneine (ET) levels may occur, particularly after 60 years.
- Lower ET levels are associated with mild cognitive impairment, suggesting a potential risk factor for neurodegenerative diseases.
- Ergothioneine deficiency may predispose individuals to neurodegenerative conditions.
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