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Updated: Mar 17, 2026
Measurement of the Pressure-volume Curve in Mouse Lungs
Published on: January 27, 2015
[Prediction of the efficiency of endoscopic lung volume reduction by valves in severe emphysema]
V Bocquillon1, A Briault1, E Reymond2
1Clinique universitaire de pneumologie, pôle thorax et vaisseaux, CHU de Grenoble, CS10217, 38043 Grenoble cedex 9, France; Université Grenoble Alpes, 38000 Grenoble, France.
Introduction:
In severe emphysema, endoscopic lung volume reduction with valves is an alternative to surgery with less morbidity and mortality. In 2015, selection of patients who will respond to this technique is based on emphysema heterogeneity, a complete fissure visible on the CT-scan and absence of collateral ventilation between lobes. Our case report highlights that individualized prediction is possible.
Case Report:
A 58-year-old woman had severe, disabling pulmonary emphysema. A high resolution thoracic computed tomography scan showed that the emphysema was heterogeneous, predominantly in the upper lobes, integrity of the left greater fissure and no collateral ventilation with the left lower lobe. A valve was inserted in the left upper lobe bronchus. At one year, clinical and functional benefits were significant with complete atelectasis of the treated lobe.
Conclusion:
The success of endoscopic lung volume reduction with a valve can be predicted, an example of personalized medicine.
