Related Experiment Video

Updated: Mar 17, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

11.6K

An effect of left ventricular hypertrophy on mild-to-moderate left ventricular diastolic dysfunction

Sharma Kattel1, Salim Memon2, Keiko Saito2

  • 1Department of Medicine, Sisters of Charity Hospital, University at Buffalo, Buffalo, NY, USA; Division of Hospital Medicine, Mayo Clinic Health System, Albert Lea/Austin, MN, USA.

Hellenic Journal of Cardiology : HJC = Hellenike Kardiologike Epitheorese
|July 23, 2016
PubMed

Insights

Left ventricular hypertrophy (LVH) may predict worsening diastolic dysfunction in patients with mild-to-moderate left ventricular diastolic dysfunction (LVDD). LVH presence correlated with higher filling pressures and impaired global function, suggesting a risk for future diastolic heart failure.

Area of Science:

  • Cardiology
  • Echocardiography
  • Heart Failure Research

Background:

  • Left ventricular diastolic dysfunction (LVDD) is linked to various conditions, often induced by left ventricular hypertrophy (LVH).
  • The predictive role of LVH in the progression of LVDD to diastolic heart failure remains unclear in patients with existing mild-to-moderate LVDD.

Purpose of the Study:

  • To investigate the impact of LVH on left ventricular diastolic function in patients diagnosed with mild-to-moderate LVDD.
  • To determine if LVH is a predictor of future LVDD deterioration.

Main Methods:

  • A comparative study involving 225 patients with LVH and 225 without LVH, all having mild-to-moderate LVDD and preserved ejection fraction.
  • LVDD assessment utilized Doppler mitral inflow and tissue Doppler patterns.
  • Key parameters evaluated included estimated left ventricular filling pressure (FP) and the Tei index for global function, alongside isovolumic relaxation time (IVRT).

Main Results:

  • Patients with LVH exhibited significantly higher left ventricular filling pressures (15.68 mmHg vs. 14.07 mmHg) compared to those without LVH.
  • The Tei index, indicating global left ventricular function, was significantly elevated in the LVH group (0.58 vs. 0.53).
  • Isovolumic relaxation time (IVRT), a measure of diastolic function, was significantly longer in the LVH group (103.93 ms vs. 95.94 ms).

Conclusions:

  • The presence of LVH in patients with mild-to-moderate LVDD is associated with elevated filling pressures and impaired global left ventricular function.
  • These findings suggest that LVH may serve as a predictor for the progression to severe LVDD and the development of diastolic heart failure.
Abstract

Keywords:
Left ventricular diastolic dysfunctionLeft ventricular filling pressureLeft ventricular hypertrophyTei index

More Related Videos

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats08:09

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

23.2K
Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery08:17

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery

Published on: February 20, 2017

15.1K

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.3K
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
1.1K
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
863
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
627
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.4K
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
725