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Cardiac Magnetic Resonance-Verified Myocardial Fibrosis in Chagas Disease: Clinical Correlates and Risk

Marly Uellendahl1,2,3, Maria Eduarda Menezes de Siqueira2,3, Eveline Barros Calado2,3

  • 1Setor de Ressonância Magnética Cardiovascular do Instituto do Coração (InCor) - Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP.

Arquivos Brasileiros De Cardiologia
|December 17, 2016
PubMed

Insights

Cardiac magnetic resonance (CMR) effectively identifies myocardial fibrosis in Chagas disease patients, correlating strongly with the Rassi score for prognostic stratification.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Parasitic Diseases

Background:

  • Chagas disease (CD) is a significant cause of heart failure and mortality, particularly in Latin America.
  • Evaluating cardiac morphology, function, and myocardial fibrosis (MF) is crucial for prognosis.
  • Cardiac magnetic resonance (CMR) offers advanced imaging for assessing these parameters.

Purpose of the Study:

  • To evaluate cardiac morphological and functional characteristics in Chagas disease patients using CMR.
  • To assess the extent of myocardial fibrosis (MF) via myocardial-delayed enhancement (MDE) with CMR.
  • To compare the prognostic value of CMR-detected MF with the Rassi score.

Main Methods:

  • 39 patients with Chagas disease were studied, divided into indeterminate (IND) and Chagas heart disease (CHD) groups.
  • All patients underwent CMR, including cine-MRI and MDE sequences.
  • The extent of MF detected by MDE was quantified and compared with the Rassi score.

Main Results:

  • Significant morphological and functional differences were observed between the IND and CHD groups (p < 0.001).
  • A strong positive correlation was found between the extent of MF and the Rassi score (r = 0.76).

Conclusions:

  • CMR is a valuable tool for evaluating Chagas disease patients across all clinical presentations.
  • The strong correlation between CMR-derived MF and the Rassi score highlights CMR's utility in prognostic stratification.
  • CMR provides detailed insights into cardiac changes and fibrosis extent in Chagas disease.
Abstract

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