Relationship between Neuropathic Pain and Obesity
Jun Hozumi1, Masahiko Sumitani2, Yoshitaka Matsubayashi3
1Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
Pain Research & Management
|July 23, 2016
Summary
Obesity significantly worsens neuropathic pain, even when not caused by musculoskeletal issues. High body mass index (BMI) patients reported more severe pain and symptoms, suggesting obesity-associated inflammation may aggravate nerve damage.
Area of Science:
- Neurology
- Pain Medicine
- Obesity Research
Background:
- Obesity is a known risk factor for musculoskeletal conditions like osteoarthritis and chronic low back pain.
- The impact of obesity on neuropathic pain, which is not directly related to mechanical load, is less understood.
Purpose of the Study:
- To investigate the relationship between obesity and neuropathic pain severity.
- To determine if higher body mass index (BMI) influences the experience of neuropathic pain.
Main Methods:
- Patients with neuropathic pain were categorized into high-BMI (BMI ≥ 25) and normal-BMI groups.
- Pain intensity was assessed using the Numeric Rating Scale (NRS) and Short-Form McGill Pain Questionnaire (SF-MPQ).
- Neuropathic Pain Symptom Inventory (NPSI) was used to evaluate pain characteristics and symptoms.
Main Results:
- The high-BMI group exhibited significantly higher NRS and NPSI scores compared to the normal-BMI group.
- Paroxysmal pain and negative symptoms were more severe in individuals with high BMI.
- SF-MPQ scores were also significantly elevated in the high-BMI cohort, indicating greater pain perception.
Conclusions:
- Obesity is associated with increased severity of neuropathic pain, independent of musculoskeletal damage.
- Obesity-associated inflammation may play a role in exacerbating neuropathic pain symptoms, particularly paroxysmal pain.
- Further research is required to confirm these findings and elucidate the underlying mechanisms.
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