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Related Concept Videos

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Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
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Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
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5-HT2A Gene Variants Moderate the Association between PTSD and Reduced Default Mode Network Connectivity.

Mark W Miller1, Emily Sperbeck2, Meghan E Robinson3

  • 1Behavioral Science Division, National Center for PTSD, VA Boston Healthcare SystemBoston, MA, USA; Department of Psychiatry, Boston University School of MedicineBoston, MA, USA.

Frontiers in Neuroscience
|July 23, 2016
PubMed
Summary
This summary is machine-generated.

Genetic variations in serotonin receptors influence brain connectivity in veterans with posttraumatic stress disorder (PTSD). Specific HTR2A gene variants impact the default mode network (DMN) and are linked to PTSD severity.

Keywords:
HTR1BHTR2Adefault mode networkfunctional connectivityposttraumatic stress disorderserotonin receptor

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • The default mode network (DMN) is crucial for understanding functional connectivity disruptions in psychiatric disorders like posttraumatic stress disorder (PTSD).
  • Serotonin system modulation of DMN connectivity is known, but the role of specific serotonin receptor gene variants in PTSD remains unexplored.

Purpose of the Study:

  • To investigate the association between serotonin receptor gene variants, PTSD, and DMN connectivity in veterans.
  • To identify specific single nucleotide polymorphisms (SNPs) that interact with PTSD to affect DMN functional connectivity.

Main Methods:

  • Examined serotonin receptor SNPs (HTR1B, HTR2A) and their interaction with PTSD in 134 veterans.
  • Utilized candidate SNP analysis and expanded to 99 HTR1B and HTR2A SNPs.
  • Performed whole-cortex vertex-wise analysis for precise localization of significant SNP × PTSD interactions.

Main Results:

  • rs7997012 (HTR2A) interacted with PTSD, reducing connectivity between the posterior cingulate cortex (PCC) and right medial prefrontal cortex/middle temporal gyrus (MTG).
  • rs130058 (HTR1B) was associated with PCC-right angular gyrus connectivity.
  • Two HTR2A SNPs (rs977003, rs7322347) moderated the association between PTSD severity and PCC-right MTG connectivity.

Conclusions:

  • HTR2A gene variants significantly influence DMN connectivity in the context of PTSD.
  • Findings advance understanding of the neurobiological role of 5-HT2A receptors in PTSD.