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PTSD Severity-Related Accelerated Aging, Hippocampal Volume, and CLDN5 DNA Methylation.

Erika J Wolf, Xiang Zhao, Shira Hao

    Biopsychosocial Science and Medicine
    |June 16, 2026
    PubMed
    Summary

    Post-traumatic stress disorder (PTSD) severity is linked to accelerated aging and altered claudin-5 (CLDN5) DNA methylation. This epigenetic change may indicate neurodegeneration, including reduced hippocampal volume, with blood DNAm serving as a potential biomarker.

    Keywords:
    AD = Alzheimer’s diseaseBBB = blood brain barrierCA = cornu ammonisCAPS = Clinician Administered PTSD ScaleCLDN-5 = claudin-5CNS = central nervous systemDNA methylationDNAm = DNA methylationDSM = Diagnostic and Statistical ManualFDR = false discovery rateML = molecular layerMP-RAGE (magnetization prepared rapid gradient echo)MRI = magnetic resonance imagingMiami-AD = Methylation in Aging and Methylation in ADNCPTSD = National Center for PTSDPC = principal componentPGC = Psychiatric Genomics ConsortiumPMI = postmortem intervalPTSDPTSD = posttraumatic stress disorderQC = quality controlTBI = traumatic brain injuryTRACTS = Translational Research Center for TBI and Stress DisordersWBC = white blood cellaccelerated agingclaudin-5hippocampal subfieldhippocampusp-adj = adjusted p-valuevmPFC = ventromedial prefrontal cortex

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