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Variations of prothrombin time, factor VII and protein C with a single daily dose of acenocoumarol. Preliminary
J N Fiessinger1, J F Vitoux, M Roncato
1Service de Médecine Interne et de Pathologie Vasculaire, Hôpital Broussais, Paris, France.
Haemostasis
|January 1, 1989
Abstract:
In 11 patients on steady anticoagulation with a daily dose of acenocoumarol, prothrombin time, factor VII and protein C were measured 2 and 16 h after the daily intake of acenoumarol. Prothrombin time (expressed as International Normalised Ratio) increases significantly, factor VII and protein C decrease between the two samples. These results suggest that a daily dose of acenoumarol is associated with fluctuation of the anticoagulant effect.