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NALP3-Inflammasome-Related Gene Polymorphisms in Patients with Prehypertension and Coronary Atherosclerosis

Xin Zhao1, Chonghuai Gu2, Chenghui Yan1

  • 1Cardiovascular Research Institute and Department of Cardiology, General Hospital of Shenyang Military Region, 83 Wenhua Road, Shenyang, Liaoning 110840, China.

Biomed Research International
|July 23, 2016
PubMed

Insights

Specific NOD2 gene haplotypes, CTACATAA and CCACATAG, were linked to coronary heart disease (CHD) in prehypertension patients. This finding suggests a potential genetic marker for CHD risk in individuals with elevated blood pressure.

Area of Science:

  • Cardiovascular Genetics
  • Inflammation and Immunology

Background:

  • Prehypertension, an early stage of hypertension, is associated with inflammation, a key factor in coronary atherosclerosis (CAS).
  • The NALP3-inflammasome pathway and its related genes (NLRP3, NOD2, CARD8) are implicated in inflammatory processes relevant to cardiovascular disease.

Purpose of the Study:

  • To investigate the association between single nucleotide polymorphisms (SNPs) and gene haplotypes in NLRP3, NOD2, and CARD8 with coronary heart disease (CHD) in prehypertensive patients.
  • To evaluate the role of the NALP3-inflammasome pathway in the development of CHD among individuals with prehypertension.

Main Methods:

  • A cohort of 576 prehypertensive patients with suspected CHD underwent coronary angiography.
  • Patients were categorized into control (<50% arterial stenosis) and case (>50% arterial stenosis) groups.
  • Fifteen polymorphisms in NOD2, NLRP3, and CARD8 genes were analyzed, alongside serum C-reactive protein (CRP) levels.

Main Results:

  • No significant association was found between individual SNPs in NOD2, NLRP3, and CARD8 and CHD risk in prehypertension.
  • However, specific NOD2 gene haplotypes, CTACATAA (p = 0.0064) and CCACATAG (p = 0.0126), showed a significant difference between CHD cases and controls.

Conclusions:

  • While individual SNPs in the studied genes were not significantly associated with CHD in prehypertension, specific NOD2 haplotypes (CTACATAA, CCACATAG) are linked to CHD.
  • These findings suggest that certain NOD2 gene haplotypes may serve as genetic markers for CHD risk in the prehypertension population.

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