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Phenotypes on demand via switchable target protein degradation in multicellular organisms

Frederik Faden1,2, Thomas Ramezani3,4, Stefan Mielke1,2

  • 1Independent Junior Research Group on Protein Recognition and Degradation, Leibniz Institute of Plant Biochemistry (IPB), Weinberg 3, D-06120 Halle (Saale), Germany.

Nature Communications
|July 23, 2016
PubMed
Summary

Scientists developed a new low-temperature-controlled degradation signal (lt-degron) system. This tool enables on-demand control of protein levels in vivo, facilitating the study and engineering of biological processes across diverse organisms.

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