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SZDB: A Database for Schizophrenia Genetic Research.

Yong Wu1,2, Yong-Gang Yao1,2,3,4, Xiong-Jian Luo1,2,4

  • 1Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, China.

Schizophrenia Bulletin
|July 25, 2016
PubMed
Summary

Schizophrenia (SZ) research is advanced by SZDB, a new database integrating genetic, gene expression, and network data. This resource aids in identifying key SZ genes and pathways for molecular diagnosis and mechanism studies.

Keywords:
databasegene expressiongenetic studyintegrative analysisschizophrenia

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Area of Science:

  • Neuroscience
  • Genetics
  • Bioinformatics

Background:

  • Schizophrenia (SZ) is a complex brain disorder with a challenging genetic basis.
  • Genome-wide association studies (GWAS) have identified numerous SZ risk loci, but extracting biological insights remains difficult.

Purpose of the Study:

  • To develop a comprehensive database (SZDB) integrating diverse data types for SZ research.
  • To facilitate the translation of genetic findings into molecular diagnosis and mechanism studies for SZ.

Main Methods:

  • Systematic extraction, curation, and deposition of SZ genetic data, gene expression, network data, brain eQTL data, and SNP annotations into SZDB.
  • In-depth data analysis and integration to prioritize SZ genes and enriched pathways.
  • Utilizing data from GWAS, CNVs, association/linkage studies, gene expression, PPI, co-expression, eQTL, and ENCODE.

Main Results:

  • SZDB was established, integrating multiple layers of SZ research data.
  • Prioritized SZ genes and enriched pathways were identified through data integration.
  • Genes implicated in SZ show high co-expression in the human brain, and their encoded proteins exhibit significant interactions.

Conclusions:

  • SZDB offers a user-friendly platform with high-confidence candidate variants and genes for functional characterization.
  • The database provides online tools for data search, browse, integration, and customized analyses, supporting SZ research.
  • SZDB facilitates a deeper understanding of SZ molecular mechanisms and aids in developing diagnostic and therapeutic strategies.