Related Experiment Video
Updated: Mar 17, 2026
Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
Published on: December 15, 2023
Soluble E-cadherin as a serum biomarker in patients with HBV-related liver diseases
Bo Wang1, Jingyi Liu1, Yuan Xiong2
1Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Objective:
Substantial evidence indicates that serum sE-cadherin is a pivotal regulator that contributes to the initiation and development of various types of diseases. However, very little is known about the relationship between levels of serum sE-cadherin and HBV-related disorders. The overall goal of the study is to get a better insight into whether or not serum sE-cadherin is involved in HBV-related diseases.
Design And Methods:
Serum levels of sE-cadherin and IFN-γ, from 113 patients with chronic hepatitis B, 101 patients with HBV-related cirrhosis, 75 patients with hepatocellular carcinoma and 125 healthy individuals were measured with commercial available sandwich ELISA kits.
Results:
sE-cadherin values were significantly higher in patients compared to healthy control (p<0.0001). The levels of serum sE-cadherin were significantly positively correlated with the serum levels of IFN-γ, alanine transaminase and aspartate aminotransferase in chronic hepatitis B and cirrhosis patients. In hepatocellular carcinoma patients, serum sE-cadherin concentrations were only significantly positively correlated with the serum levels of ALT and AST.
Conclusions:
Serum sE-cadherin levels maybe an important indicator of the pathogenesis of progression of HBV-related disorders.
More Related Videos
05:55Identifying Inhibitors of the HBx-DDB1 Interaction Using a Split Luciferase Assay System
Published on: December 21, 2019
11:34A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
Published on: May 10, 2022
