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Updated: Mar 17, 2026
Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke
Published on: February 10, 2023
New mechanical thrombectomy model in the rabbit: A feasibility study
T Haider1, R Plasenzotti2, H Bergmeister3
1University Clinic for Trauma Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria; Cerebrovascular Research Group, Krankenanstalt Rudolfstiftung, Juchgasse 25, A-1030 Vienna, Austria; Ludwig Boltzmann Cluster for Cardiovascular Research, Vienna, Austria.
Researchers developed a new, cost-effective rabbit model for preclinical testing of mechanical thrombectomy devices. This simplified model mimics human coagulation and offers comparable vessel sizes for stroke research.
Area of Science:
- Biomedical Engineering
- Translational Research
- Preclinical Models
Background:
- Thrombolytic therapy for ischemic stroke has limitations, including bleeding risks and low recanalization rates.
- Mechanical thrombectomy is an emerging treatment option with improving device technology.
- Extensive preclinical in vivo testing is crucial for new mechanical thrombectomy devices.
Purpose of the Study:
- To establish a simplified and cost-effective rabbit model for preclinical evaluation of mechanical thrombectomy devices.
- To translate the existing pig model to a more accessible animal model.
Main Methods:
- Eight adult female New Zealand white rabbits underwent thromboembolisation.
- Artificial, radiopaque thrombi were created using autologous blood and barium sulfate.
- Thrombi were delivered via catheter through the femoral artery, followed by 2D digital subtraction angiography (DSA).
Main Results:
- The procedure was technically feasible with no observed complications or mortality.
- Thromboemboli were successfully located in the maxillary artery (87.5%) and occipital artery (12.5%).
- In vivo thrombus length averaged 7.0±4.55mm, with vessel diameters of 2.44±0.21mm (common carotid) and 2.1±0.16mm (maxillary).
Conclusions:
- A novel rabbit model for mechanical thrombectomy is technically feasible, cost-effective, and safe.
- The model provides comparable vessel diameters to human cranial arteries.
- This rabbit model closely mimics the human coagulation system, making it suitable for preclinical stroke research.
