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Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology
Published on: November 14, 2025
863
High-Throughput Microfluidic Device for Circulating Tumor Cell Isolation from Whole Blood
Daniel K Yang1, Serena Leong2, Lydia L Sohn1
1Dept. of Mechanical Engineering, University of California, Berkeley, CA 94720 USA.
Micro Total Analysis Systems : Proceedings of the ... [Mu] TAS International Conference on Miniaturized Chemical and Biochemical Analysis Systems. [Mu] TAS (Conference)
|July 26, 2016
Abstract:
Circulating tumor cells (CTCs) are promising markers to determine cancer patient prognosis and track disease response to therapy. We present a multi-stage microfluidic device we have developed that utilizes inertial and Dean drag forces for isolating CTCs from whole blood. We demonstrate a 94.2% ± 2.1% recovery of cancer cells with our device when screening whole blood spiked with MCF-7 GFP cells.
