Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

2.3K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.3K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.3K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.3K
Mitochondrial Membranes01:45

Mitochondrial Membranes

17.6K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
17.6K
Mitochondria01:37

Mitochondria

21.2K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
21.2K
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

4.7K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
4.7K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

19.4K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
19.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advancing CO<sub>2</sub> emission data quality in cement production through integrated material-, flue gas-, and 3D inventory-based monitoring.

Environmental monitoring and assessment·2026
Same author

Lysine acetyltransferase 8-mediated histone acetylation, regulated by GBA1, is associated with lysosomal function related to α-Synuclein pathology.

Cell death & disease·2026
Same author

Photoinduced Structural Relaxation in Chiral Copper(l) Iodide Cluster Scintillators for Circularly Polarized Radioluminescence Imaging.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

ZDHHC5-mediated BRAF palmitoylation activates the MAPK pathway and drives cholangiocarcinoma progression.

Cancer letters·2026
Same author

The effects of citrulline on horse milk components and fecal metabolism were analyzed based on LC-MS and 16s amplicon.

BMC veterinary research·2026
Same author

Surface charge engineering improves the alkaline resistance of Pseudoalteromonas tetraodonis κ-carrageenase for application in hydrolysis of κ-carrageenan industrial waste residues.

Food research international (Ottawa, Ont.)·2026
Same journal

Lysophagy protects against ANXA11 amyloid fibril toxicity and propagation in FTLD.

Translational neurodegeneration·2026
Same journal

Metabolic crosstalk in the ageing brain: astrocyte-neuron coupling as a target for homeostatic restoration and therapy.

Translational neurodegeneration·2026
Same journal

Targeting lysosomal pH restores mitochondrial quality control in GBA1-mutant Parkinson's disease.

Translational neurodegeneration·2026
Same journal

Persistent PirB cleavage drives Golgi-directed trafficking deficits underlying neurodegeneration.

Translational neurodegeneration·2026
Same journal

From phenotype to biology: a multi-modal roadmap of biofluid, tissue, imaging, and digital biomarkers in Parkinson's disease.

Translational neurodegeneration·2026
Same journal

Ketogenic diet as a therapeutic strategy for neurodegenerative diseases: from mechanisms to translational challenges.

Translational neurodegeneration·2026
See all related articles

Related Experiment Video

Updated: Mar 17, 2026

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
06:07

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease

Published on: June 23, 2023

2.4K

Mitochondrial dysfunction in Parkinson's disease.

Qingsong Hu1, Guanghui Wang2

  • 1Laboratory of Molecular Neuropathology, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215021 China.

Translational Neurodegeneration
|July 26, 2016
PubMed
Summary
This summary is machine-generated.

Parkinson's disease involves the loss of specific neurons and is linked to mitochondrial dysfunction. Genetic and environmental factors contribute to this dysfunction, highlighting mitochondria's role in Parkinson's pathogenesis.

Keywords:
MPTPMitochondrial complex I inhibitorMitochondrial deficiencyMitophagyNeurodegenerationParkinson’s disease

More Related Videos

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
15:09

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

17.5K
Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
08:19

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry

Published on: May 5, 2022

2.9K

Related Experiment Videos

Last Updated: Mar 17, 2026

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
06:07

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease

Published on: June 23, 2023

2.4K
The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
15:09

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

17.5K
Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
08:19

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry

Published on: May 5, 2022

2.9K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Genetics

Background:

  • Parkinson's disease (PD) is the second leading neurodegenerative disorder.
  • It is characterized by dopaminergic neuron loss and Lewy body formation.
  • The exact cause of PD remains elusive, but research points to mitochondrial dysfunction.

Purpose of the Study:

  • To review factors associated with Parkinson's disease.
  • To summarize recent advancements in understanding mitochondrial dysfunction in PD pathogenesis.
  • To explore the link between genetic/environmental factors and mitochondrial impairment in PD.

Main Methods:

  • Literature review of studies on Parkinson's disease.
  • Analysis of research on mitochondrial dysfunction and its role in PD.
  • Examination of genetic factors (PINK1, parkin) and environmental toxins impacting mitochondria.

Main Results:

  • Mitochondrial dysfunction is implicated in dopaminergic neuron loss in PD.
  • Inhibition of mitochondrial complex I by neurotoxins directly links mitochondrial dysfunction to PD.
  • Decreased mitochondrial complex I activity is observed in PD brains and models.
  • PINK1 and parkin genes are crucial for mitophagy, the process of clearing damaged mitochondria.

Conclusions:

  • Mitochondrial dysfunction is a key player in Parkinson's disease pathogenesis.
  • Both genetic predispositions and environmental exposures can lead to mitochondrial impairment in PD.
  • Understanding mitophagy pathways involving PINK1 and parkin offers insights into PD mechanisms.