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ZDHHC5-mediated BRAF palmitoylation activates the MAPK pathway and drives cholangiocarcinoma progression

Chunxi Li1, Xiezong Hu1, Ziqiou Zhang1

  • 1Department of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, State Key Laboratory of Immune Responses and Immunotherapy, Centre for Leading Medicine and Advanced Technologies of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China; Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Hefei, Anhui, 230001, China; Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Institute of Cancer Research, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.

Cancer Letters
|May 14, 2026
PubMed

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