Electrodeposition of Biocomposite Film Onto ZnO Nanoparticles Modified Electrode for Closed-Loop Insulin Delivery

In this study, glucose responsive bioinorganic composite (BIM) was prepared through chitosan microparticles coupling concanavalin A, enzymes and dextran-insulin via specific affinity. The drug-delivery device was fabricated by electrodeposition of BIM onto the nanostructured ZnO on indium tin oxide (ITO) substrate. The release profiles of device revealed that the insulin release was in response to the glucose concentration in vitro experiment. The released insulin still remained the activity after running the whole process and the device showed the capability for glucose sensing continuously. All these results suggest that the device may be a promising system for self-regulated insulin delivery and glucose monitoring.