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Single Versus Multiple Hyperbaric Sessions for Carbon Monoxide Poisoning in a Murine Model
Shaun D Carstairs1,2, Alexander D Miller3, Alicia B Minns4
1Division of Medical Toxicology, Department of Emergency Medicine, University of California, San Diego, CA, USA. shaunc@yahoo.com.
Summary
Hyperbaric oxygen (HBO) therapy may not prevent delayed neurologic sequelae after carbon monoxide (CO) poisoning. This study found no significant difference in outcomes between one or multiple HBO treatments compared to normobaric oxygen.
Area of Science:
- Neurology
- Toxicology
- Hyperbaric Medicine
Background:
- Acute carbon monoxide (CO) poisoning can lead to delayed neurologic sequelae (DNS).
- Hyperbaric oxygen (HBO) therapy is debated for its efficacy in preventing CO poisoning-induced DNS.
- Optimal HBO treatment protocols, including the number of sessions, remain unclear.
Purpose of the Study:
- To investigate the effectiveness of one versus multiple HBO sessions in preventing DNS in a mouse model of CO poisoning.
- To compare HBO treatment with normobaric oxygen (NBO) and no treatment.
Main Methods:
- Fifty mice were divided into five groups: control, CO poisoning only, CO + NBO, CO + one HBO session, and CO + three HBO sessions.
- Animals were trained in motor tasks (step-down latency and step-up latency) before CO exposure and treatment.
- Neurologic outcomes were assessed one week post-treatment by retesting motor task performance.
Main Results:
- No significant differences were found among groups for step-down latency.
- A significant difference was observed in step-up latency among groups.
- However, post-hoc analysis revealed no statistically significant differences between any individual groups, including comparisons between one and three HBO sessions.
Conclusions:
- Neither one nor multiple HBO sessions demonstrated a statistically significant benefit over normobaric oxygen in preventing delayed neurologic sequelae in this mouse model.
- The study suggests HBO may not be effective for preventing DNS after CO poisoning, and potentially could worsen outcomes.
- Further research is needed to elucidate the role and optimal timing of HBO in CO poisoning management.
