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Biotransformation of beta-nortestosterone by cultured porcine hepatocytes
L A Hoogenboom1, M C Berghmans, W A Traag
1State Institute for Quality Control of Agricultural Products (RIKILT), Wageningen, The Netherlands.
Journal of Chromatography
|April 7, 1989
Abstract:
The metabolism of beta-nortestosterone by porcine hepatocytes was investigated. Initially beta-nortestosterone was rapidly oxidized to norandrostenedione, which was further transformed into a number of more hydrophilic compounds. It is assumed that most of these compounds were glucuronides, considering the effect of beta-glucuronidase treatment. The main product of enzymatic cleavage was investigated by gas chromatography-mass spectrometry but could not be identified until now.