Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

2.3K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
2.3K
Lethal Alleles02:41

Lethal Alleles

19.1K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
19.1K
Multiple Allele Traits01:49

Multiple Allele Traits

38.6K
The Concept of Multiple Allelism
38.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The evolving role of chemotherapy and hematopoietic cell transplants in Ph-positive acute lymphoblastic leukemia in adults.

Bone marrow transplantation·2017
Same author

Very late relapse of AML after allogeneic hematopoietic cell transplantation is often extramedullary.

Bone marrow transplantation·2016
Same author

Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition.

Leukemia·2015
Same author

PHF6 mutations in adult acute myeloid leukemia.

Leukemia·2010
Same author

Mutational analysis of candidate tumor-associated genes in acute megakaryoblastic leukemia.

Leukemia·2009
Same author

Phase II study of theophylline in chronic lymphocytic leukemia: a study of the Eastern Cooperative Oncology Group (E4998).

Leukemia·2004

Related Experiment Video

Updated: Mar 17, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.8K

Ambiguous Phenotypes In Acute Leukemia.

E Paietta1

  • 1a Department of Oncology, Montefiore Medical Center, and Department of Medicine. Division of Medical Oncology, Albert Einstein College of Medicine, Bronx, New York, IJSA.

Leukemia & Lymphoma
|July 27, 2016
PubMed
Summary
This summary is machine-generated.

Ambiguous leukemic phenotypes, including biphenotypic and hybrid leukemias, present challenges in classification. Research explores mechanisms like aberrant differentiation or genetic changes causing these complex cell profiles.

Keywords:
Acute leukemiaphenotype

More Related Videos

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

895
In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)
06:48

In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)

Published on: August 1, 2025

638

Related Experiment Videos

Last Updated: Mar 17, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.8K
Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

895
In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)
06:48

In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)

Published on: August 1, 2025

638

Area of Science:

  • Hematology
  • Cancer Biology
  • Immunophenotyping

Background:

  • Ambiguous leukemic phenotypes are difficult to classify using standard systems.
  • Terms like biphenotypia, mixed lineage, and hybrid leukemias describe these non-normative phenotypes.
  • Existing literature discusses the interpretation and clinical significance of these challenging cases.

Purpose of the Study:

  • To review the phenomenon of ambiguous leukemic phenotypes.
  • To discuss the controversial hypotheses regarding their underlying mechanisms.
  • To explore the clinical significance of these non-standard leukemic presentations.

Main Methods:

  • Literature review of existing studies and reviews on ambiguous leukemic phenotypes.
  • Analysis of proposed mechanisms for coexpression of antigens from multiple cell lineages.
  • Discussion of terminology and classification challenges in leukemia.

Main Results:

  • Ambiguous leukemic phenotypes are characterized by the coexpression of antigens from more than one cell lineage on single leukemic blasts.
  • Hypotheses for their origin include a relationship with normal primitive hematopoietic differentiation stages or acquired genetic alterations.
  • These phenotypes challenge established classification systems, necessitating further investigation.

Conclusions:

  • Ambiguous leukemic phenotypes represent a complex area in hematologic oncology.
  • Understanding their mechanisms is crucial for accurate diagnosis and potential therapeutic strategies.
  • Further research is needed to clarify their clinical significance and biological underpinnings.