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An AIE-active fluorescence turn-on bioprobe mediated by hydrogen-bonding interaction for highly sensitive detection
Zhegang Song1, Ryan T K Kwok, Dan Ding
1Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study, Division of Biomedical Engineering, Division of Life Science, State Key Laboratory of Molecular Neuroscience and Institute of Molecular Functional Materials, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China. tangbenz@ust.hk.
Abstract:
An AIE-active "turn-on" bioprobe is designed for hydrogen peroxide detection based on an imine-functionalized tetraphenylethene derivative. The linear fluorescence response enables quantification of hydrogen peroxide with superior sensitivity and selectivity. Meanwhile, glucose assay is also realized by taking advantage of GOx/glucose enzymatic reaction.
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