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Association of TLR polymorphisms with bronchopulmonary dysplasia
Amr Hosny Malash1, Aliaa Adel Ali1, Rania Mohamed Samy2
1Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.
Background:
Bronchopulmonary dysplasia (BPD) remains a leading cause of morbidity and mortality during infancy. Evidence suggests that the Toll-like receptor (TLR) signaling pathway plays an integral role in lung inflammation and injury. This study aimed to detect single nucleotide polymorphisms (SNPs) in TLR pathway genes [TLR5 and Toll-interleukin 1 receptor domain-containing adaptor protein (TIRAP)] among preterm neonates and to determine their association with the development and severity of bronchopulmonary dysplasia.
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