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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
Pregnancy with autoimmune hepatitis
António Costa Braga1, Carlos Vasconcelos2, Jorge Braga1
1Obstetrics Department, Centro Materno Infantil do Norte - Centro Hospitalar do Porto (CHP), Oporto, Portugal.
Aim:
The aim of this study was to review our experience with gestations in autoimmune hepatitis patients.
Background:
There are only limited data describing pregnancy in patients with autoimmune hepatitis.
Patients And Methods:
Retrospective analysis of pregnancies with autoimmune hepatitis followed in Centro Hospitalar do Porto, Portugal in the last ten years.
Results:
We reported nine pregnancies in seven patients with autoimmune hepatitis. Two patients had documented liver cirrhosis prior to the pregnancy. In this study, 66.7% of patients were treated with azathioprine and 88.9% with prednisolone. Clinical improvements were observed in 11.1% of pregnancies and 22.2% exacerbations were diagnosed. There were six live births and two preterm deliveries (preterm delivery rate of 33%). We also report three first trimester miscarriages (early gestation miscarriage rate of 33%). There were no neonatal or maternal deaths.
Conclusion:
The favorable obstetric outcome is a realistic expectation in patients with autoimmune hepatitis. Tight monitoring and control of asymptomatic and unpredictable exacerbations, which are unrelated to the severity of the underlying disease, are essential to the prognosis of the current pregnancy.
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