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Ceanothane-type triterpenoids from Cyphostemma adenocaule.
Jean Rodolphe Chouna1, Flore Nardella2,3, Bruno Ndjakou Lenta4
1Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
Archives of Pharmacal Research
|July 28, 2016
Summary
Two new triterpenoids, cyphostemmic acids A and B, were isolated from Cyphostemma adenocaule. These compounds and others showed weak antiplasmodial activity against Plasmodium falciparum.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Medicinal Chemistry
Background:
- Cyphostemma adenocaule is a liana with potential medicinal properties.
- Triterpenoids are a diverse class of natural products with various biological activities.
- Plasmodium falciparum is a parasite responsible for severe malaria.
Purpose of the Study:
- To isolate and characterize new compounds from Cyphostemma adenocaule.
- To evaluate the antiplasmodial activity of isolated compounds and their derivatives.
Main Methods:
- Methanol extraction of Cyphostemma adenocaule bark and wood.
- Isolation and purification of compounds using spectroscopic techniques (1D and 2D NMR).
- Ozonolysis for semisynthetic derivative preparation.
- In vitro antiplasmodial activity testing against Plasmodium falciparum 3D7.
Main Results:
- Two new ceanothane-type triterpenoids, cyphostemmic acid A (1) and cyphostemmic acid B (2), were identified.
- Known triterpenoids, β-sitosterol, and its glucoside were also isolated.
- Semisynthetic derivatives (8-10) were prepared from compounds 1, 3, and 6.
- Compounds 1-4, 6, and 8-10 exhibited weak antiplasmodial activity.
Conclusions:
- The phytochemical investigation of Cyphostemma adenocaule yielded novel triterpenoids.
- The isolated compounds and their derivatives demonstrated limited in vitro antiplasmodial activity.
- Further research may explore structural modifications for enhanced efficacy.
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