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Enantioseparations in open-tubular capillary electrochromatography: Recent advances and applications
Constantina P Kapnissi-Christodoulou1, Athina G Nicolaou1, Ioannis J Stavrou1
1Department of Chemistry, University of Cyprus, 1678 Nicosia, Cyprus.
Abstract:
This review highlights recent advances and applications in open-tubular capillary electrochromatography (OT-CEC) for enantioseparations during the last decade. Although extensive research has been conducted in the area of separations by use of CEC, and a big number of reviews have been published, there is not a review on exclusively the use of chiral stationary phases (CSPs) in OT-CEC for enantioseparations. Therefore, in this review, the design and synthesis of different CSPs are presented, and their potential applications in OT-CEC for enantioseparations are discussed. The different approaches to CSP development include chiral nanomaterials, porous layers, molecular imprinting, sol-gel technique, polyelectrolyte multilayer coating, polymeric coating and others.
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