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A Murine Orthotopic Bladder Tumor Model and Tumor Detection System
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Urinary Bladder Xanthoma - Is Immunohistochemistry Necessary?

M Raghavendran1, A Venugopal2, Vinay N Kaushik3

  • 1Department of Urology, Apollo BGS Hospitals, Adichunchunagiri Road, Kuvempunagar, Mysore 570009, Karnataka, India.

Urology Case Reports
|July 28, 2016
PubMed
Summary

Urinary bladder xanthomas (UBX) are rare, non-cancerous growths. This report details their cystoscopic appearance and discusses the diagnostic role of immunohistochemistry for these lipid-associated bladder lesions.

Keywords:
Benign lesionsCystoscopyHistopathologyImmunohistochemistryUrinary Bladder NeoplasmsXanthoma

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Area of Science:

  • Uropathology
  • Gastroenterology

Background:

  • Urinary Bladder Xanthomas (UBX) are rare, non-neoplastic, reactive processes.
  • Isolated UBX cases are exceptionally infrequent, with approximately 15 reported instances.
  • UBX typically affect older individuals presenting with nonspecific symptoms such as urinary tract infections or hematuria.

Observation:

  • Patients with UBX often exhibit associated lipid anomalies.
  • Macroscopically, UBX are described as yellowish-white plaques or patches within the bladder.
  • Recent literature emphasizes the utility of Immunohistochemistry (IHC) in diagnosing UBX.

Findings:

  • This report aims to present a detailed cystoscopic view of UBX for improved identification.
  • The study will discuss the diagnostic value and application of IHC in confirming UBX.

Implications:

  • Enhanced cystoscopic visualization can aid in the early and accurate diagnosis of UBX.
  • Clarifying the role of IHC strengthens diagnostic protocols for these rare bladder lesions.
  • Understanding UBX contributes to the broader knowledge of reactive bladder pathologies and lipid metabolism disorders.