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Updated: Mar 17, 2026

Subcellular Fractionation of Primary Chronic Lymphocytic Leukemia Cells to Monitor Nuclear/Cytoplasmic Protein Trafficking
Published on: October 23, 2019
Cytokines in B-Cell Chronic Lymphocytic Leukemia
R Foa1, A G Tos1, P Francia di Celle1
1a Dipartimento di Scienze Biomediche ed Oncologia Umana, Sezione di Clinica Medica, and Centro CNR "Immunogenetica ed Istocompatibilitá", University of Torino, Italy.
Abstract:
The pleomorphic action of different cytokines in regulating the growth and proliferation of normal B- and T-lymphocyte populations is becoming progressively more apparent. Thus, the possibility that some cytokines, either alone or in variable combination, may play a role in different lymphoproliferative disorders has been increasingly suggested and potential autocrine or paracrine loops hypothesized. Here, we shall discuss some of the known B-cell growth factors which have been postulated to be involved in the hematological progression, clinical course and complications in B-cell lymphocytic leukemia.
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