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Published on: November 9, 2019
Enantioselective Organocatalyzed Transformations of β-Ketoesters
Thavendran Govender1, Per I Arvidsson1,2, Glenn E M Maguire1
1Catalysis and Peptide Research Unit, University of KwaZulu Natal , Durban, 4001, South Africa.
Abstract:
The β-ketoester structural motif continues to intrigue chemists with its electrophilic and nucleophilic sites. Proven to be a valuable tool within organic synthesis, natural product, and medicinal chemistry, reports on chiral β-ketoester molecular skeletons display a steady increase. With the reignition of organocatalysis in the past decade, asymmetric methods available for the synthesis of this structural unit has significantly expanded, making it one of the most exploited substrates for organocatalytic transformations. This review provides comprehensive information on the plethora of organocatalysts used in stereoselective organocatalyzed construction of β-ketoester-containing compounds.
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