Related Experiment Video
Updated: Mar 17, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
Published on: March 17, 2020
The Role of Growth Factors in Bone-Marrow Transplantation
A Golidstone1, J Gribben1, A Mcmillan1
1a Department of Haematology, University College Hospital, London, UK.
Abstract:
Growth factors may be of value in reducing transplant-related complications. Recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) and recombinant granulocyte colony-stimulating factor (G-CSF) are the most widely studied growth factors to date, and show promise in terms of accelerating haemopoietic recovery; however, their overall value is less clear. Non-recombinant colony-stimulating factors derived from human urine are also under investigation. Any antileukaemic or immune modulatory role for growth factors is currently speculative. The value of growth factors in allogeneic bone-marrow transplantation has not yet been adequately investigated. The use of growth factcm in combination is potentially of great value but as yet there are no human data. In addition to having proliferative effects, some colony-stimulating factors have important effects on mature phagocyte function. Large randomized studies will be needed to document the real value of growth factors in marrow transplanation.
More Related Videos
10:32Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate
Published on: May 19, 2023
09:34Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
Published on: September 7, 2017
Related Concept Videos
Role of Hematopoietic Growth Factors
Thrombopoietin (TPO), mainly released by the liver,...
Regulation of Hematopoietic Stem Cells
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
Stem Cell Therapy for Tissue Regeneration
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Mitogens and the Cell Cycle
Differentiation of Common Myeloid Progenitor Cells