Related Experiment Video
Updated: Mar 17, 2026
06:48
In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)
Published on: August 1, 2025
638
Autologous Bone-Marrow Transplantation in Acute Lymphoblastic Leukaemia: 1980-89
A K Mcmillan1, J G Gribben1, D C Linch1
1a University College Hospital, London, UK.
Leukemia & Lymphoma
|July 28, 2016
Summary
Conventional therapy for adult acute lymphoblastic leukaemia (ALL) shows poor outcomes. Intensive chemotherapy with autologous bone-marrow rescue also yielded limited long-term survivors, suggesting no superiority over standard treatments.
Area of Science:
- Hematology
- Oncology
- Bone Marrow Transplantation
Background:
- Conventional therapy for adult acute lymphoblastic leukaemia (ALL) yields disappointing results.
- Allogeneic bone-marrow transplantation offers improved outcomes but is limited by donor availability.
Purpose of the Study:
- To investigate the efficacy of intensive chemotherapy and chemo/radiotherapy protocols with autologous bone-marrow rescue in adult ALL patients.
- To compare the outcomes of autologous bone-marrow rescue with conventional therapy.
Main Methods:
- Treatment of 31 adult ALL patients using intensive chemotherapy and chemo/radiotherapy with autologous bone-marrow rescue.
- Patients were divided into two groups: 14 treated beyond first remission and 17 in first remission.
Main Results:
- The intensive therapy protocols resulted in poor outcomes in both patient groups.
- Only two long-term survivors were observed in each treatment arm.
- The study found no evidence that ablative therapy with autologous bone-marrow rescue is superior to conventional therapy for adult ALL.
Conclusions:
- Intensive chemotherapy and chemo/radiotherapy with autologous bone-marrow rescue do not appear to improve outcomes in adult acute lymphoblastic leukaemia.
- Further research involving total body irradiation (TBI) containing regimens is necessary to evaluate potential benefits.
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