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Laser spectrophotometry in the fetus
Journal of Perinatal Medicine
|January 1, 1989
Summary
Near-infrared laser spectrophotometry offers a new noninvasive method for assessing fetal biochemical and biophysical status. This technology shows potential for monitoring blood volume and hemoglobin changes, aiding in fetal health assessment.
Area of Science:
- Biomedical Engineering
- Medical Physics
- Clinical Diagnostics
Background:
- Near-infrared (NIR) laser spectrophotometry is a novel technology for clinical use.
- The system comprises a NIR data collection unit (NIRDCU) and a personal computer.
Purpose of the Study:
- To evaluate the potential of NIR laser spectrophotometry for noninvasive fetal monitoring.
- To assess the feasibility of obtaining information on intracellular redox state and blood volume changes.
Main Methods:
- Utilized a NIRDCU emitting laser light at 775, 805, 845, and 904 nm.
- Analyzed changes in optical density during laser radiation on the fetal head.
- Measured relative changes in hemoglobin concentrations, blood volume, and cytochrome aa3.
Main Results:
- Demonstrated the potential for obtaining signals related to relative hemoglobin and blood volume changes.
- Indicated achievable measurements of cytochrome aa3 status.
- Initial measurements on the fetal head provided a preliminary impression of the method's capabilities.
Conclusions:
- NIR laser spectrophotometry shows promise as a noninvasive tool for fetal assessment.
- Potential for developing safe, low-cost, and portable instruments for monitoring fetal biochemical and biophysical status.
- Further development is needed to overcome challenges with laser sensor application.