Related Experiment Video
Updated: Mar 17, 2026

Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction
Published on: January 12, 2020
Association Between Kidney Cancer and Occupational Exposure to Trichloroethylene
Morten Buhagen1, Anna Grønskag, Siri Fenstad Ragde
1Department of Occupational Medicine, St. Olavs University Hospital in Trondheim (Mr Buhagen, Dr Grønskag, Ms Ragde, Dr Hilt); and Department of General Practice and Community Medicine, Faculty of Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway (Mr Buhagen, Drs Grønskag, Hilt).
Objective:
This study investigates the association between occupational exposure to trichloroethylene (TCE) and kidney cancer, as this correlation has been questioned.
Methods:
The incidence of cancers was studied in a dynamic cohort of 997 male workers who for many years had been occupationally exposed to TCE.
Results:
During a 50-year observation period, 13 cases of kidney cancer were observed (7.5 expected) with a standardized incidence ratio of 1.7 and a 95% confidence interval of 1.0 to 3.0. Four other cases, not included in the SIR analysis, were also observed. Long-term TCE exposure was positively confirmed for 14 of the 17 incident cases. There is reason to assume that the remaining cases also had been exposed to TCE.
Conclusions:
The present study supports the view that TCE is a kidney carcinogen.
Related Concept Videos
Kidney Transplant I: Introduction
Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease I: Introduction
Cancer Prevention
Some...
Chronic Kidney Disease III: Interprofessional Care
Types of Toxins
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...

