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[Association between chronic urinary tract infection and primary biliary cirrhosis]

Y Xu1, J B Wang1, S Wang2

  • 1Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun 130033, China.

Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology
|July 29, 2016
PubMed

Insights

Primary biliary cirrhosis (PBC) may be linked to urinary tract infections (UTI). This study explores the connection between recurrent UTIs and PBC, investigating potential underlying mechanisms for this autoimmune liver disease association.

Area of Science:

  • Hepatology
  • Immunology
  • Microbiology

Background:

  • The exact causes of primary biliary cirrhosis (PBC) are unknown, but genetic, infectious, autoimmune, and environmental factors are implicated.
  • Infections, particularly chronic microbial infections, are considered a major factor in PBC development.
  • Recurrent urinary tract infections (UTIs), often caused by Escherichia coli, are recognized risk factors for autoimmune liver diseases, including PBC.

Purpose of the Study:

  • To investigate the potential association between urinary tract infections (UTIs) and primary biliary cirrhosis (PBC).
  • To explore the possible mechanisms linking recurrent UTIs to the development and progression of PBC.

Main Methods:

  • Literature review and analysis of existing studies on UTI and PBC.
  • Examination of epidemiological data and etiological factors.

Main Results:

  • Evidence suggests a correlation between recurrent UTIs and an increased risk of PBC.
  • Escherichia coli is identified as a common pathogen in UTIs linked to autoimmune liver conditions.

Conclusions:

  • Urinary tract infections represent a significant area of investigation for understanding the etiology of primary biliary cirrhosis.
  • Further research is warranted to elucidate the precise mechanisms by which UTIs contribute to PBC pathogenesis.

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