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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
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Diterpenoids of terrestrial origin.

James R Hanson1

  • 1Department of Chemistry, University of Sussex, UK.

Natural Product Reports
|July 29, 2016
PubMed
Summary

This review details the isolation and chemistry of terrestrial diterpenoids, including labdanes, clerodanes, and abietanes, from January to December 2015. It covers various cyclization products and related compounds, referencing 214 scientific sources.

Area of Science:

  • Natural Product Chemistry
  • Organic Chemistry

Background:

  • Diterpenoids are a diverse class of natural products with significant biological activities.
  • Terrestrial sources are rich reservoirs of structurally unique diterpenoids.

Purpose of the Study:

  • To comprehensively review the isolation and chemical characterization of terrestrial diterpenoids.
  • To document advancements in diterpenoid chemistry from January to December 2015.

Main Methods:

  • Literature search and compilation of published studies on terrestrial diterpenoids.
  • Analysis of reported isolation techniques and structural elucidation methods.
  • Classification of diterpenoids based on their core skeletons (e.g., labdanes, clerodanes).

Main Results:

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  • Detailed account of newly isolated and characterized diterpenoids from terrestrial origins.
  • Inclusion of various diterpenoid subclasses such as labdanes, clerodanes, abietanes, pimaranes, kauranes, and cembranes.
  • Documentation of cyclization products and their chemical transformations.

Conclusions:

  • The year 2015 saw continued significant contributions to the field of terrestrial diterpenoid chemistry.
  • This review consolidates current knowledge, providing a valuable resource for researchers in natural products and organic chemistry.