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Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model
Published on: November 26, 2010
Tetraspanin CD81, a modulator of immune suppression in cancer and metastasis
Felipe Vences-Catalán1, Ranjani Rajapaksa1, Minu K Srivastava1
1Department of Medicine, Division of Oncology, Stanford University Medical Center , Stanford, CA, USA.
Abstract:
Cancer cells can escape the antitumor immune response by recruiting immune suppressor cells. However, although innate myeloid-derived suppressor cells (MDSCs) and T regulatory (Treg) cells accumulate normally in tumor-bearing CD81-deficient mice, both populations are impaired in their ability to suppress the antitumor immune response.
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